Lubiprostone stimulates small intestinal mucin release
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چکیده
منابع مشابه
Lubiprostone stimulates small intestinal mucin release
BACKGROUND Lubiprostone is a synthetic bicyclic fatty acid derivative of prostaglandin E1 (PGE1) used for chronic constipation. The best known action of lubiprostone is simulation of Cl- dependent fluid secretion. In a mouse model of the genetic disease cystic fibrosis, we previously showed that in vivo administration of lubiprostone resulted in greater mucus accumulation in the small intestine...
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BACKGROUND/AIMS Lubiprostone, a chloride channel type 2 (ClC-2) activator, was thought to treat constipation by enhancing intestinal secretion. It has been associated with increased intestinal transit and delayed gastric emptying. Structurally similar to prostones with up to 54% prostaglandin E2 activity on prostaglandin E receptor 1 (EP1), lubiprostone may also exert EP1-mediated procontractil...
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ژورنال
عنوان ژورنال: BMC Gastroenterology
سال: 2012
ISSN: 1471-230X
DOI: 10.1186/1471-230x-12-156